Mapk14 ELISA Kit for Mouse(Mus musculus) | EIAab.comMapk14 ELISA Kit for Mouse(Mus musculus)

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Mapk14 (Gene name),

Mitogen-activated protein kinase 14 (Protein name ), MK14_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapk14(Crk1;Csbp1;Csbp2);

Protein name:

Mitogen-activated protein kinase 14(MAP kinase 14;MAPK 14);

Alternative:

Mitogen-activated protein kinase p38 alpha(MAP kinase p38 alpha);CRK1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with NP60 (By similarity). Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 and FAM48A.

Function:

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

360

Sequence:

50:

100:

150:

200:

250:

300:

350:

360:

PPLDQEEMES |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.311337

KEGG:

mmu:26416

SMR:

P47811

STRING:

10090.ENSMUSP00000004990

Pfam:

PF00069

String:

P47811

Uniprot:

P47811

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ELISA Kit for Mouse MAP kinase 14

Cat.:

E9114h

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96T

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ELISA Kit for Mouse MAP kinase 14

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ELISA Kit for Mouse MAP kinase 14

Cat.:

E9114m

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Packing:

96T

ELISA Kit for Mouse MAP kinase 14

Cat.:

E9114r

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96T

CLIA Kit for Mouse MAP kinase 14

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CLIA Kit for Mouse MAP kinase 14

Cat.:

U9114h

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Manual:

Looking for manual.

MSDS:

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96T

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CLIA Kit for Mouse MAP kinase 14

Cat.:

U9114m

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MSDS:

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96T

CLIA Kit for Mouse MAP kinase 14

Cat.:

U9114r

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96T

Polyclonal Antibody for Mouse MAP kinase 14

Cat.:

P9114Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 14

Cat.:

P9114Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 14

Monoclonal Antibody for Mouse MAP kinase 14

Protein for Mouse MAP kinase 14

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells."
Han J. , Lee J.-D. , Bibbs L. , Ulevitch R.J.
Science265:808-811(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
tissue: Liver.
2.

Higashitsuji H. , Fujita J.
Submitted (1996-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
strain: C57BL/6.
tissue: Brain.
3.

"Piccolo, a new alternative spliced form of p38/CSBP1/Mxi2 that is specifically expressed in kidney and liver."
Faccio L. , Fusco C. , Zervos S.A.
Submitted (1999-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: C57BL/6.
tissue: Kidney.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
strain: C57BL/6J.
tissue: Bone marrow.
tissue: Pituitary.
tissue: Thymus.
5.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Liver.
7.

Yin Z. , Li J. , Sha J. , Zhou Z. , Lin M. , Wang L.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 94-318 (ISOFORM 3)
tissue: Testis.
8.

"Novel CDC2-related protein kinases produced in murine hematopoietic stem cells."
Ershler M.A. , Nagorskaya T.V. , Visser J.W.M. , Belyavsky A.V.
Gene124:305-306(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-186
strain: CBA.
tissue: Bone marrow.
9.

"Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."
Derijard B. , Raingeaud J. , Barrett T. , Wu I.-H. , Han J. , Ulevitch R.J. , Davis R.J.
Science267:682-685(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
10.

"A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase."
Blanco-Aparicio C. , Torres J. , Pulido R.
J. Cell Biol.147:1129-1136(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRR;SUBCELLULAR LOCATION
11.

"Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells."
Allen M. , Svensson L. , Roach M. , Hambor J. , McNeish J. , Gabel C.A.
J. Exp. Med.191:859-870(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
tissue: Embryonic stem cell.
12.

"Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis."
Tamura K. , Sudo T. , Senftleben U. , Dadak A.M. , Johnson R. , Karin M.
Cell102:221-231(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
strain: C57BL/6J.
13.

"MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts."
Wiggin G.R. , Soloaga A. , Foster J.M. , Murray-Tait V. , Cohen P. , Arthur J.S.
Mol. Cell. Biol.22:2871-2881(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF RPS6KA5/MSK1 AND RPS6KA4/MSK2
14.

"JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors."
Lee C.M. , Onesime D. , Reddy C.D. , Dhanasekaran N. , Reddy E.P.
Proc. Natl. Acad. Sci. U.S.A.99:14189-14194(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPAG9
15.

"The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway."
Salvador J.M. , Mittelstadt P.R. , Belova G.I. , Fornace A.J. Jr. , Ashwell J.D.
Nat. Immunol.6:396-402(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GADD45A;PHOSPHORYLATION AT TYR-323;AUTOPHOSPHORYLATION;ENZYME REGULATION;FUNCTION
16.

"p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation."
Zohn I.E. , Li Y. , Skolnik E.Y. , Anderson K.V. , Han J. , Niswander L.
Cell125:957-969(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUPT20H
17.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
18.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
19.

"Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states."
Zhang Y.Y. , Mei Z.Q. , Wu J.W. , Wang Z.X.
J. Biol. Chem.283:26591-26601(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-180 AND TYR-182;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
20.

"In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance."
Shi Y. , Gaestel M.
Biol. Chem.383:1519-1536(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
21.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
22.

"Mechanisms and functions of p38 MAPK signalling."
Cuadrado A. , Nebreda A.R.
Biochem. J.429:403-417(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
23.

"The structure of mitogen-activated protein kinase p38 at 2.1-A resolution."
Wang Z. , Harkins P.C. , Ulevitch R.J. , Han J. , Cobb M.H. , Goldsmith E.J.
Proc. Natl. Acad. Sci. U.S.A.94:2327-2332(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)
24.

"Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b."
Chang C.I. , Xu B.E. , Akella R. , Cobb M.H. , Goldsmith E.J.
Mol. Cell9:1241-1249(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH MEF2A AND MAP2K3
25.

"The development of monocyclic pyrazolone based cytokine synthesis inhibitors."
Golebiowski A. , Townes J.A. , Laufersweiler M.J. , Brugel T.A. , Clark M.P. , Clark C.M. , Djung J.F. , Laughlin S.K. , Sabat M.P. , Bookland R.G. , VanRens J.C. , De B. , Hsieh L.C. , Janusz M.J. , Walter R.L. , Webster M.E. , Mekel M.J.
Bioorg. Med. Chem. Lett.15:2285-2289(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH INHIBITOR
26.

"The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production."
Laughlin S.K. , Clark M.P. , Djung J.F. , Golebiowski A. , Brugel T.A. , Sabat M. , Bookland R.G. , Laufersweiler M.J. , VanRens J.C. , Townes J.A. , De B. , Hsieh L.C. , Xu S.C. , Walter R.L. , Mekel M.J. , Janusz M.J.
Bioorg. Med. Chem. Lett.15:2399-2403(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) IN COMPLEX WITH INHIBITOR
27.

"Molecular basis of MAPK-activated protein kinase 2:p38 assembly."
White A. , Pargellis C.A. , Studts J.M. , Werneburg B.G. , Farmer B.T. II
Proc. Natl. Acad. Sci. U.S.A.104:6353-6358(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-360 IN COMPLEX WITH MAPKAPK2
28.

"A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5."
Zhang Y.Y. , Wu J.W. , Wang Z.X.
Sci. Signal.4:RA88-RA88(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) IN COMPLEX WITH DUSP10;CATALYTIC ACTIVITY;DEPHOSPHORYLATION BY DUSP10;INTERACTION WITH DUSP10

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